January 22, 2019
By: Team PathSOS

Cervical Cancer | Role of HPV Testing in Cervical Cancer Screening - PathSOS

Screening for cervical cancer was originally started by Papanicolaou in 1943 after the publication of the book "Diagnosis of uterine cancer" by vaginal smear and was responsible for a dramatic fall in the incidence and mortality caused by cervical cancer in western countries.

India is the country afflicted by the largest number of cervical carcinomas, the annual incidence being up to 55 women per lakh of women population. It is the third most common cancer among women. Developing countries account for 85% of the cervical cancer burden. The distribution, incidence, and prevalence of carcinoma cervix depend upon the economic status, sexual habits, and availability of medical screening-treatment facilities.

There are many factors that can contribute to the development of cervical cancer. HPV infection is the main etiological factor which is an essential prerequisite.

Other prominent risk factors include:

  • Early age at first intercourse
  • Early age at first pregnancy
  • History of high numbers of Sexual partners
  • History of cigarette smoking
  • History of oral contraceptive use
  • History of radiation exposure
  • Certain human leukocyte antigen (HLA) subtypes
  • Low socioeconomic status

Role of HPV testing in cervical cancer screening:

Role of HPV testing has become well established today.  HPV testing alone is of no value in the general population, because around 10-16% of the population in the target age group has HPV infection, most of the latent type, which is not significant. HPV is significant when low grade squamous intraepithelial lesion (LSIL) is found on cytology, associated with high-risk strains of HPV. Around two-thirds of all LSIL is caused by high-risk HPV types while the remainder is caused by low-risk type of HPV which do not increase the risk for cancer.

Cancer may be the most confusing and frightening word in medicine. People who are diagnosed with cancer often experience tremendous physical, emotional and physical challenges, as well as a sense of urgency to get into treatment as soon as possible.  Treatments are constantly getting better, and it is important to find someone who has experience with your type of cancer. During this time, getting a medical second opinion may be an essential and necessary component of treating one’s diagnosis.

How a Medical Second Opinion may help?

Many people feel reluctant and resistant to seek a cancer diagnosis second opinion. A cancer diagnosis second opinion could correct a misdiagnosis and provide better treatment options available.

PathSOS experts review your medical records and diagnostic tests and render a comprehensive "medical second opinion" that includes the best treatment options and recommendations regarding future therapeutic considerations.  PathSOS's cancer diagnosis second opinion will use the latest available knowledge to confirm the diagnosis.

A second opinion may provide the following information:

  • Confirmation of a diagnosis
  • Type of cancer and its stage
  • The exact location of the cancer
  • Malignancy of cancer
  • Other treatment options

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